Acne Products

CLINEX LOTION

Clindamycin

Description:

Clinex lotion, a topical antibiotic contains Clindamycin Phosphate, which has anti-acne and antibacterial activity. It binds to the 50S subunit of the bacterial ribosome and inhibits the early stage of protein synthesis. It is active against most aerobic gram-positive bacteria as well as has good activity against anaerobic bacteria.

Composition:

Each ml lotion contains Clindamycin Phosphate USP equivalent to Clindamycin 10 mg

Pharmacology:

Clindamycin Phosphate rapidly hydrolizes to active clindamycin in vivo by tissue phosphatase. Clindamycin acts as anti-acne agent due to its antibacterial activity. Topical Clindamycin lotion is thought to reduce free fatty acid concentration on the skin and to suppress the growth of Propionibacterium acnes (Corynebacterium acnes), an anaerobe found in sebaceous glands and follicles.

Indications:

Acne vulgaris: Clinex lotion is indicated in the treatment of acne vulgaris, which are characterized by inflammatory lesions such as papules and pustules.

Skin infection: Clinex lotion is used in the topical treatment of erythrasma caused by Corynebacterium minutissimum; rosacea, periorificial dermatitis, folliculitis, stasis, chronic lymphaedema and familial pemphigus.

Clinex lotion is also used in the treatment of dermal ulcers.

Dosage and Direction for use:

Cleanse the face or affected area gently with warm water or soap as recommended by the physician. After the skin is dried, apply a thin film of Clinex lotion to the affected areas twice daily, in the morning and in the evening.  Do not wash within three hours after using lotion. The treatment period is usually 6 weeks or advised by the physician.

Side-effects:

Serious side effects are not likely to occur. Some rare side effects are dryness, erythema, burning, peeling, oily skin, etching, diarrhoea, colitis, GI disturbances.

Contraindications:

Patients who have hypersensitivity to Clindamycin or Lincomycin, history of regional enteritis or ulceration colitis or antibiotic associated colitis.

Precautions:

Pregnancy: There is no adequate study on safety of Clindamycin in pregnant women.

Lactation: It is not known whether the agent is excreted in human milk, so caution should be exercised when administering to a nursing mother.

Children: Safety and effectiveness in children under 12 years have not been established.

Drug Interaction:

Clindamycin should be used with caution in patients receiving neuromuscular agents and erythromycin.

Patient Information:

• This medication to be used as directed by physician. It is for external use only.

• Avoid contact with eyes, nose, mouth, and other mucous membranes.

• Wash hands immediately after use.

• Patient should report any signs of local adverse reactions or abdominal pain or diarrhoea to the physician.

Storage:

• Store at room temperature (20-25º C).

• Keep the container tightly closed.

• Protect from freezing.

Packing:

Bottle containing 25 ml lotion.